The GABAA receptors
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چکیده
منابع مشابه
The GABAA receptors.
INTRODUCTION y-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. It mediates its effects via the specific interaction with the integral membrane proteins, the GABA receptors. GABA receptors can be classified according to their respective transduction mechanisms following activation, as the GABA and the GABAB receptor respectively. The focus of this review...
متن کاملGabaa and Gabab Receptors
Since the introduction of the alpha function by Rall in 1967 12], there has been signii-cant progress in our understanding of the molecular events underlying synaptic transmission. Particular receptor types have been identiied and their activation kinetics characterized. It is now possible to develop models of these receptors, using a formalism similar to that introduced by Hodgkin and Huxley 9...
متن کاملGABAB Receptors Regulate Extrasynaptic GABAA Receptors.
Tonic inhibitory GABA(A) receptor-mediated currents are observed in numerous cell types in the CNS, including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells, and cerebellar granule cells. Here we show that in rat brain slices, activation of postsynaptic GABA(B) receptors enhances the magnitude of the tonic GABA(A) current recorded in these cell types via a path...
متن کاملThe Role of GABAA Receptors in Schizophrenia
Schizophrenia is a neurodevelopmental disorder triggered by environmental factors in the pre-, perior postnatal periods and manifesting as changes in brain chemistry and morphology. A deficit in the GABAergic system is strongly implicated in schizophrenia, resulting in perturbed inhibitory transmission. GABAA receptors are altered in post-mortem brains of persons with schizophrenia. Increased b...
متن کاملDopamine directly modulates GABAA receptors.
Dopamine is a critical neuromodulator that activates GPCRs in mammals or ligand-gated ion channels in invertebrates. The present study demonstrates that dopamine (0.1-10 mm) exerts novel, opposing effects on different populations of mammalian (rat) GABAA receptors. Using whole-cell patch-clamp electrophysiology, we observed direct dopamine-mediated inhibition of tonic-level (1 μm) GABA-evoked c...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1995
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3100001